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n-1-2-020.18a
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1995-07-21
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020.18: Molecular Biology: ICGEBnet
by Sandor Pongor, Gyorgy Simon and Arturo Falaschi
<pongor@icgeb.trieste.it>
<simon@icgeb.trieste.it>
<falaschi@icgeb.trieste.it>
The International Centre for Genetic Engineering and
Biotechnology (ICGEB) is an institute operated by the United
Nations Industrial Development Organization to help developing
countries strengthen their research abilities in molecular
biology and to provide information on various biotech-related
issues such as biosafety and patenting. ICGEB has two research
components, situated in Trieste, Italy and New Delhi, India.
One of the fundamental tools in molecular biology is access to
gene sequence databases. Mega-projects, such as the sequencing
of the human genome in the US, are pouring data into the
databanks. Every time a new gene or protein sequence is
determined experimentally, researchers must search these
databanks for similar sequences.
This task is far beyond the reach of small computers and is best
done by using centralized computer resources such as maintained
by EMBL (the European Molecular Biology Laboratory) in Europe or
GenBank in the US. In addition to access to the databases, these
systems provide services such as electronic mail, bulletin
boards, and access to file archives.
ICGEB provides a similar resource for developing countries.
ICGEBnet provides on-line access to the major sequence data
banks, including the EMBL nucleic acid sequence databank which is
updated daily. ICGEBnet is a node of EMBnet, the informatics
network of the European Molecular Biology Organization.
In addition to the EMBL data bank, ICGEB supports a wide variety
of other data resources, such as the HIV sequence databases
HIV-NA and HIV-AA, the Japanese Protein Research Foundation's
protein sequence database SEQDB, and the SBASE protein domain
library (developed at ICGEB).
On-line software includes packages for representing and
manipulating nucleic acid and protein sequence data, as well as
FASTA and TFASTA for sequence similarity searching, and CLUSTAL
for multiple sequence alignment. Other utilities include
electronic mail, a bulletin board, and the gopher service.
Access to ICGEBnet resources is available to all ICGEB member
country scientists; however, preference will be given to those
scientists whose research is directly related to the research
goals of ICGEB. The principal mechanism for remote access to the
ICGEBnet is via the Italian ITAPAC X.25 PDN, permitting up to 16
simultaneous incoming connections. In addition, ICGEBnet can also
be accessed over the Internet via the International Centre for
Theoretical Physics. At the end of 1991, ICGEBnet had 300
registered users. ICGEBnet also serves as a training facility.
The system is used extensively during the 15 or so ICGEB courses
organized yearly, two of which are usually dedicated to computer
applications. A computer lab at ICGEB can host up to 25
students.
ICGEBnet is maintained by ICGEB's Computer Services in
collaboration with ICGEB's Protein Structure and Function Group.
The joint research is focused on search methods for distant
protein sequence homologies.
(S.P. is Head of Protein Structure/Function Group, G.S. is
Systems Manager and A.F. is General Director, ICGEB, Padriciano
99, Area di Ricerca, 34012 Trieste, Italy)